CHM 1

Name CHM 1
Supplier Tocris Bioscience
Catalog 5573
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Inducer
Cas Number 154554-41-3
Chemical Name 6-(2-Fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one
Formula C16H10FNO3
Molecular Weight 283.25
Purity >99 %
Description Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo . Causes cell cycle arrest at G 2 /M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.
Supplier Page Shop

Product References

CHM-1, a novel synthetic quinolone with potent and selective antimitotic - CHM-1, a novel synthetic quinolone with potent and selective antimitotic

Wang SW, Pan SL, Huang YC, Guh JH, Chiang PC, Huang DY, Kuo SC, Lee KH, Teng CM. Mol Cancer Ther. 2008 Feb;7(2):350-60.

CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein - CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein

Tsai AC, Pan SL, Sun HL, Wang CY, Peng CY, Wang SW, Chang YL, Kuo SC, Lee KH, Teng CM. J Biol Chem. 2010 Feb 19;285(8):5497-506.