CHMFL-FLT3-122

Name CHMFL-FLT3-122
Supplier Tocris Bioscience
Catalog 3868
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1839150-56-9
Chemical Name 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone
Formula C26H29N7O2
Molecular Weight 471.55
Description Potent and selective FLT3 inhibitor (IC 50 = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro . Induces apoptosis by arresting cell cycle in G 0 /G 1 phase in vitro . Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable.
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Product References

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Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat - Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat

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