(-)-[3 R ,4 S ]-Chromanol 293B

• Supplier: Tocris Bioscience
• Catalog: 1412
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Cas Number: 163163-24-4
• Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
• Formula: C15H20N2O4S
• Molecular Weight: 324.39
• Purity: >99 %
• Description: Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at K V 11.1 (hERG) channels (IC 50 > 30 μ M). Racemate Chromanol 293B (Cat. No. 1412) also available.

Product References

Stereoselective interactions of the enantiomers of chromanol 293B with human - Stereoselective interactions of the enantiomers of chromanol 293B with human

Yang IC, Scherz MW, Bahinski A, Bennett PB, Murray KT. J Pharmacol Exp Ther. 2000 Sep;294(3):955-62.

Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols. - Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols.

Lerche C, Seebohm G, Wagner CI, Scherer CR, Dehmelt L, Abitbol I, Gerlach U, Brendel J, Attali B, Busch AE. Br J Pharmacol. 2000 Dec;131(8):1503-6.

A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the - A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the

Seebohm G, Lerche C, Pusch M, Steinmeyer K, Bruggemann A, Busch AE. Br J Pharmacol. 2001 Dec;134(8):1647-54.