CI 1020

• Supplier: Tocris Bioscience
• Catalog: 1475
• Prices: $89.00, $189.00, $765.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 162256-50-0
• Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
• Formula: C28H26O9
• Molecular Weight: 506.5
• Purity: >98 %
• Description: Highly selective, orally active, non-peptide endothelin-A receptor (ET A ) antagonist (IC 50 values are 0.3 and 480 nM for ET A and ET B receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.

Product References

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) - Discovery of a novel series of orally active non-peptide endothelin-A (ETA)

Doherty AM, Patt WC, Edmunds JJ, Berryman KA, Reisdorph BR, Plummer MS, Shahripour A, Lee C, Cheng XM, Walker DM, et al.. J Med Chem. 1995 Apr 14;38(8):1259-63.

The effect of the endothelin ET(A) receptor antagonist CI-1020 on hypoxic - The effect of the endothelin ET(A) receptor antagonist CI-1020 on hypoxic

Jones RD, Wanstall JC, Gambino A, Morice AH. Eur J Pharmacol. 1999 Jun 25;374(3):367-75.

The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) - The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034)

Coe Y, Haleen SJ, Welch KM, Liu YA, Coceani F. J Pharmacol Exp Ther. 2002 Aug;302(2):672-80.