CI 988

• Supplier: Tocris Bioscience
• Catalog: 2227
• Prices: $269.00, $1,105.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 130332-27-3
• Chemical Name: 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoicacid
• Formula: C35H42N4O6
• Molecular Weight: 614.73
• Purity: >99 %
• Description: Potent and selective CCK 2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK 1 receptors (IC 50 values are 1.7 and 2717 nM for CCK 2 and CCK 1 respectively). Has negligible affinity at a range of other binding sites (IC 50 > 10 μ M). Exhibits anxiolytic activity following oral administration.

Product References

CI-988 inhibits growth of small cell lung cancer cells. - CI-988 inhibits growth of small cell lung cancer cells.

Moody TW, Jensen RT. J Pharmacol Exp Ther. 2001 Dec;299(3):1154-60.

Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in - Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in

Andre J, Zeau B, Pohl M, Cesselin F, Benoliel JJ, Becker C. J Neurosci. 2005 Aug 31;25(35):7896-904.