CI 994

• Supplier: Tocris Bioscience
• Catalog: 2607
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 112522-64-2
• Chemical Name: 4-(Acetylamino)-N-(2-aminophenyl)benzamide
• Formula: C15H15N3O2
• Molecular Weight: 269.3
• Purity: >99 %
• Description: Orally active class I histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo . Increases neuroplasticity during memory extinction.

Product References

Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) - Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl)

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Distinct pharmacological properties of second generation HDAC inhibitors with the - Distinct pharmacological properties of second generation HDAC inhibitors with the

Beckers T, Burkhardt C, Wieland H, Gimmnich P, Ciossek T, Maier T, Sanders K. Int J Cancer. 2007 Sep 1;121(5):1138-48.

Epigenetic priming of memory updating during reconsolidation to attenuate remote - Epigenetic priming of memory updating during reconsolidation to attenuate remote

Graff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, Haggarty SJ, Tsai LH. Cell. 2014 Jan 16;156(1-2):261-76.