| Name | CID 16020046 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2952 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 834903-43-4 |
| Chemical Name | 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoicacid |
| Formula | C25H19N3O4 |
| Molecular Weight | 425.44 |
| Purity | >99 % |
| Description | Selective GPR55 antagonist. Inhibits LPI-induced Ca 2+ signaling (IC 50 = 0.21 μ M in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ -opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice. |
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Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, Heinemann A. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.
Stancic A, Jandl K, Hasenohrl C, Reichmann F, Marsche G, Schuligoi R, Heinemann A, Storr M, Schicho R. Neurogastroenterol Motil. 2015 Jul 30.