| Name | CID 2745687 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4644 |
| Prices | $175.00, $709.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 264233-05-8 |
| Chemical Name | 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylicacidmethylester |
| Formula | C17H19F2N5O2S |
| Molecular Weight | 395.43 |
| Purity | >98 % |
| Description | Competitive, reversible antagonist of the orphan receptor GPR35 (K i = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β -arrestin recruitment induced by pamoic acid (Cat. No. 4298). |
| Supplier Page | Shop |
Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME. Mol Pharmacol. 2010 Oct;78(4):560-8.
Jenkins L, Harries N, Lappin JE, MacKenzie AE, Neetoo-Isseljee Z, Southern C, McIver EG, Nicklin SA, Taylor DL, Milligan G. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95.