Cilengitide

• Supplier: Tocris Bioscience
• Catalog: 2709
• Prices: $185.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 188968-51-6
• Formula: C27H40N8O7
• Molecular Weight: 588.66
• Description: Potent and selective inhibitor of integrins α v β 3 and α v β 5 (IC 50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Product References

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway - Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway

Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. doi:

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. - Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.

Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Nature. 2012 Mar 18;484(7392):125-9.