Cilostamide

• Supplier: Tocris Bioscience
• Catalog: 2629
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 68550-75-4
• Chemical Name: N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
• Formula: C20H26N2O3
• Molecular Weight: 342.44
• Description: Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC 50 values are 0.027 and 0.050 μ M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μ M); antithrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Product References

Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, - Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase,

Hidaka H, Hayashi H, Kohri H, Kimura Y, Hosokawa T, Igawa T, Saitoh Y. J Pharmacol Exp Ther. 1979 Oct;211(1):26-30.

Potent effects of novel anti-platelet aggregatory cilostamide analogues on - Potent effects of novel anti-platelet aggregatory cilostamide analogues on

Sudo T, Tachibana K, Toga K, Tochizawa S, Inoue Y, Kimura Y, Hidaka H. Biochem Pharmacol. 2000 Feb 15;59(4):347-56.