| Name | Cinacalcet hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0902 |
| Prices | $89.00, $375.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 364782-34-3 |
| Chemical Name | N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-aminehydrochloride |
| Formula | C22H22F3N.HCl |
| Molecular Weight | 393.87 |
| Purity | >98 % |
| Description | Calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC 50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable. |
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O'Donnell M. Ann N Y Acad Sci. 1991;629:413-5.
O'Donnell M, Crowley HJ, Yaremko B, O'Neill N, Welton AF. J Pharmacol Exp Ther. 1991 Nov;259(2):751-8.