Cisplatin

• Supplier: Tocris Bioscience
• Catalog: 1695
• Prices: $89.00
• Sizes: 50 mg
• Cas Number: 15663-27-1
• Chemical Name: cis-Diaminodichloroplatinum
• Formula: Cl2H6N2Pt
• Molecular Weight: 300.05
• Description: Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis.

Product References

Cisplatin (CDDP) specifically induces apoptosis via sequential activation of - Cisplatin (CDDP) specifically induces apoptosis via sequential activation of

Seki K, Yoshikawa H, Shiiki K, Hamada Y, Akamatsu N, Tasaka K. Cancer Chemother Pharmacol. 2000;45(3):199-206.

Impairment of both apoptotic and cytoprotective signalings in glioma cells - Impairment of both apoptotic and cytoprotective signalings in glioma cells

Duan L, Aoyagi M, Tamaki M, Yoshino Y, Morimoto T, Wakimoto H, Nagasaka Y, Hirakawa K, Ohno K, Yamamoto K. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):234-43.