| Name | Cl-4AS-1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2632 |
| Prices | $209.00, $879.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 188589-66-4 |
| Chemical Name | (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide |
| Formula | C26H33ClN2O2 |
| Molecular Weight | 441.01 |
| Purity | >99 % |
| Description | Potent steroidal androgen receptor agonist (IC 50 = 12 nM). Mimics the action of 5 α -dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5 α -reductase type I and II (IC 50 values are 6 and 10 nM respectively). |
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Tolman RL, Sahoo SP, Bakshi RK, Gratale D, Patel G, Patel S, Toney J, Chang B, Harris GS. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9.
Schmidt A, Harada S, Kimmel DB, Bai C, Chen F, Rutledge SJ, Vogel RL, Scafonas A, Gentile MA, Nantermet PV, McElwee-Witmer S, Pennypacker B, Masarachia P, Sahoo SP, Kim Y, Meissner RS, Hartman GD, Duggan ME, Rodan GA, Towler DA, Ray WJ. J Biol Chem. 2009 Dec 25;284(52):36367-76.