Cladribine

• Supplier: Tocris Bioscience
• Catalog: 3812
• Prices: $95.00, $399.00
• Sizes: 10 mg, 50 mg
• Cas Number: 4291-63-8
• Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
• Formula: C10H12ClN5O3
• Molecular Weight: 285.69
• Purity: >99 %
• Description: Adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC 50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC 50 = 0.11 - 0.28 μ M). Displays activity in vitro and in vivo . Orally bioavailable.

Product References

Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing - Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing

Seto S, Carrera CJ, Kubota M, Wasson DB, Carson DA. J Clin Invest. 1985 Feb;75(2):377-83.

Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and - Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and

Bryson HM, Sorkin EM. Drugs. 1993 Nov;46(5):872-94.

Older and new formulations of cladribine. Pharmacology and clinical efficacy in - Older and new formulations of cladribine. Pharmacology and clinical efficacy in

Robak T, Korycka A, Robak E. Recent Pat Anticancer Drug Discov. 2006 Jan;1(1):23-38.