Clemizole hydrochloride

Name Clemizole hydrochloride
Supplier Tocris Bioscience
Catalog 1453
Prices $89.00, $375.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 1163-36-6
Chemical Name 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazolehydrochloride
Formula C19H20ClN3.HCl
Molecular Weight 362.3
Purity >99 %
Description TRPC5 channel blocker (IC 50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μ M for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H 1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.
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Product References

Pharmacological investigation into the effects of histamine and histamine - Pharmacological investigation into the effects of histamine and histamine

Aguilar MJ, Morales-Olivas FJ, Rubio E. Br J Pharmacol. 1986 Jul;88(3):501-6.

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential - Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential

Baraban SC, Dinday MT, Hortopan GA. Nat Commun. 2013;4:2410.

Clemizole hydrochloride is a novel and potent inhibitor of transient receptor - Clemizole hydrochloride is a novel and potent inhibitor of transient receptor

Richter JM, Schaefer M, Hill K. Mol Pharmacol. 2014 Nov;86(5):514-21.