2-Cl-IB-MECA

Name 2-Cl-IB-MECA
Supplier Tocris Bioscience
Catalog 1673
Prices $345.00, $1,405.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 163042-96-4
Chemical Name 1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide
Formula C18H18ClIN6O4
Molecular Weight 544.74
Purity >98 %
Description High affinity and extremely selective A 3 adenosine receptor agonist (K i = 0.33 nM). Displays 2500- and 1400-fold selectivity over A 1 and A 2A receptors respectively. Exhibits high selectivity over the Na + -independent adenosine transporter.
Supplier Page Shop

Product References

2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 - 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3

Kim HO, Ji XD, Siddiqi SM, Olah ME, Stiles GL, Jacobson KA. J Med Chem. 1994 Oct 14;37(21):3614-21.

Hemodynamic effects and histamine release elicited by the selective adenosine A3 - Hemodynamic effects and histamine release elicited by the selective adenosine A3

Van Schaick EA, Jacobson KA, Kim HO, IJzerman AP, Danhof M. Eur J Pharmacol. 1996 Jul 25;308(3):311-4.

Adenosine A3 receptors: novel ligands and paradoxical effects. - Adenosine A3 receptors: novel ligands and paradoxical effects.

Jacobson KA. Trends Pharmacol Sci. 1998 May;19(5):184-91.