Clocinnamox mesylate

Name Clocinnamox mesylate
Supplier Tocris Bioscience
Catalog 0752
Prices $149.00
Sizes 2 mg
Function Type Antagonist
Cas Number 117332-69-1
Chemical Name 14β-(p-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylmorphinonemesylate
Formula C29H29ClN2O4.CH3SO3H
Molecular Weight 601.11
Purity >98 %
Description Systemically active, irreversible μ -opioid receptor antagonist (apparent K i values are 0.7, 1.9 and 5.7 nM for mouse μ , δ and κ receptors respectively).
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Product References

Very long-acting narcotic antagonists: the 14 beta-p-substituted - Very long-acting narcotic antagonists: the 14 beta-p-substituted

Aceto MD, Bowman ER, May EL, Harris LS, Woods JH, Smith CB, Medzihradsky F, Jacobson AE. Arzneimittelforschung. 1989 May;39(5):570-5.

Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu - Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu

Burke TF, Woods JH, Lewis JW, Medzihradsky F. J Pharmacol Exp Ther. 1994 Nov;271(2):715-21.

Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and - Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and

Zernig G, Burke T, Lewis JW, Woods JH. J Pharmacol Exp Ther. 1996 Oct;279(1):23-31.

Methocinnamox is a potent, long-lasting, and selective antagonist of - Methocinnamox is a potent, long-lasting, and selective antagonist of

Broadbear JH, Sumpter TL, Burke TF, Husbands SM, Lewis JW, Woods JH, Traynor JR. J Pharmacol Exp Ther. 2000 Sep;294(3):933-40.