| Name | Clofarabine |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0898 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Cas Number | 123318-82-1 |
| Chemical Name | 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine |
| Formula | C10H11ClFN5O3 |
| Molecular Weight | 303.68 |
| Purity | >99 % |
| Description | Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors. |
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Parker WB, Shaddix SC, Chang CH, White EL, Rose LM, Brockman RW, Shortnacy AT, Montgomery JA, Secrist JA 3rd, Bennett LL Jr. Cancer Res. 1991 May 1;51(9):2386-94.
Bonate PL, Arthaud L, Cantrell WR Jr, Stephenson K, Secrist JA 3rd, Weitman S. Nat Rev Drug Discov. 2006 Oct;5(10):855-63.