Clotrimazole

• Supplier: Tocris Bioscience
• Catalog: 2295
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 23593-75-1
• Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
• Formula: C22H17ClN2
• Molecular Weight: 344.84
• Purity: >99 %
• Description: Imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca 2+ -activated K + current (IC 50 = 3 μ M) and L-type Ca 2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo . Also an inverse agonist of the human constitutive androstane receptor (hCAR).

Product References

Clotrimazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium - Clotrimazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium

Snajdrova L, Xu A, Narayanan N. J Biol Chem. 1998 Oct 23;273(43):28032-9.

The antifungal antibiotic clotrimazole potently inhibits L-type calcium current - The antifungal antibiotic clotrimazole potently inhibits L-type calcium current

Thomas GP, Karmazyn M, Zygmunt AC, Antzelevitch C, Narayanan N. Br J Pharmacol. 1999 Apr;126(7):1531-3.

Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary - Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary

Wu SN, Li HF, Jan CR, Shen AY. Neuropharmacology. 1999 Jul;38(7):979-89.

Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and - Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and

Lempiainen H, Molnar F, Macias Gonzalez M, Perakyla M, Carlberg C. Mol Endocrinol. 2005 Sep;19(9):2258-72. Epub 2005 May 19.