Clozapine N -oxide

Name Clozapine N -oxide
Supplier Tocris Bioscience
Catalog 5530
Prices $139.00, $579.00
Sizes 10 mg, 50 mg
Cas Number 34233-69-7
Chemical Name 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Formula C18H19ClN4O
Molecular Weight 342.82
Purity >99 %
Description Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM 4 DREADDs in vitro . Suppresses food intake in hyperphagic mice with hM 3 Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.
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Product References

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. - The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine.

Eiermann B, Engel G, Johansson I, Zanger UM, Bertilsson L. Br J Clin Pharmacol. 1997 Nov;44(5):439-46.

Evolving the lock to fit the key to create a family of G protein-coupled - Evolving the lock to fit the key to create a family of G protein-coupled

Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. Epub 2007 Mar 2.

LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium - LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium

Zaman T, Zhou X, Pandey NR, Qin Z, Keyhanian K, Wen K, Courtney RD, Stewart AF, Chen HH. J Neurosci. 2014 Jan 1;34(1):140-8.