| Name | CLP 257 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4936 |
| Prices | $185.00, $755.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Activator |
| Cas Number | 1181081-71-9 |
| Chemical Name | (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone |
| Formula | C14H14FN3O2S |
| Molecular Weight | 307.34 |
| Purity | >98 % |
| Description | Selective KCC2 K + -Cl - cotransporter activator (EC 50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABA A receptors, as well as 55 other receptors. Enhances Cl - transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury. |
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