4-CMTB

• Supplier: Tocris Bioscience
• Catalog: 4373
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 300851-67-6
• Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide
• Formula: C14H15ClN2OS
• Molecular Weight: 294.8
• Purity: >98 %
• Description: Free fatty acid receptor FFA2 agonist (pEC 50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Product References

Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 - Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2

Milligan G, Stoddart LA, Smith NJ. Br J Pharmacol. 2009 Sep;158(1):146-53.

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a - Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a

Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Trankle C, Tikhonova IG, Adams DR, Milligan G. Mol Pharmacol. 2011 Jul;80(1):163-73.