Co 101244 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1045
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 193356-17-1
• Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinolhydrochloride
• Formula: C21H27NO3.HCl
• Molecular Weight: 377.91
• Purity: >99 %
• Description: Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC 50 values are 0.043, > 100 and > 100 μ M for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro .

Product References

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, - 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel,

Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. J Med Chem. 1999 Jul 29;42(15):2993-3000.

Pharmacological characterization of Ro 63-1908 - Pharmacological characterization of Ro 63-1908

Gill R, Alanine A, Bourson A, Buttelmann B, Fischer G, Heitz MP, Kew JN, Levet-Trafit B, Lorez HP, Malherbe P, Miss MT, Mutel V, Pinard E, Roever S, Schmitt M, Trube G, Wybrecht R, Wyler R, Kemp JA. J Pharmacol Exp Ther. 2002 Sep;302(3):940-8.

Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent - Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent

Higgins GA, Ballard TM, Huwyler J, Kemp JA, Gill R. Neuropharmacology. 2003 Mar;44(3):324-41.