COG 133

Name COG 133
Supplier Tocris Bioscience
Catalog 3003
Prices $209.00
Sizes 1 mg
Cas Number 514200-66-9
Formula C97H181N37O19
Molecular Weight 2169.73
Description Apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α 7 nicotinic acetylcholine receptors (IC 50 = 445 nM).
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Product References

Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine - Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine

Gay EA, Klein RC, Yakel JL. J Pharmacol Exp Ther. 2006 Feb;316(2):835-42. Epub 2005 Oct 25.

Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory - Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory

Li FQ, Sempowski GD, McKenna SE, Laskowitz DT, Colton CA, Vitek MP. J Pharmacol Exp Ther. 2006 Sep;318(3):956-65. Epub 2006 Jun 1.

N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide - N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide

Sheng Z, Prorok M, Brown BE, Castellino FJ. Neuropharmacology. 2008 Aug;55(2):204-14.