Colivelin

Name Colivelin
Supplier Tocris Bioscience
Catalog 1364
Prices $269.00
Sizes 500 µg
Function Type Activator
Cas Number 867021-83-8
Formula C119H206N32O35
Molecular Weight 2645.13
Description Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β -peptide (1-43) at a concentration of 100 fM in vitro . Suppresses neuronal death by activating STAT3 in vitro ; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.
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Product References

Development of a femtomolar-acting humanin derivative named colivelin by - Development of a femtomolar-acting humanin derivative named colivelin by

Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M. J Neurosci. 2005 Nov 2;25(44):10252-61.

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's - Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's

Yamada M, Chiba T, Sasabe J, Terashita K, Aiso S, Matsuoka M. Neuropsychopharmacology. 2008 Jul;33(8):2020-32. Epub 2007 Oct 10.

A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of - A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of

Sari Y, Chiba T, Yamada M, Rebec GV, Aiso S. Neuroscience. 2009 Dec 29;164(4):1653-64. doi: