Combretastatin A4

• Supplier: Tocris Bioscience
• Catalog: 3945
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Cas Number: 117048-59-6
• Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
• Formula: C18H20O5
• Molecular Weight: 316.35
• Purity: >99 %
• Description: Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Inhibits tubulin polymerization.

Product References

Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin - Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin

Dorr RT, Dvorakova K, Snead K, Alberts DS, Salmon SE, Pettit GR. Invest New Drugs. 1996;14(2):131-7.

Potent anti-metastatic activity of combretastatin-A4. - Potent anti-metastatic activity of combretastatin-A4.

Griggs J, Brindle KM, Metcalfe JC, Hill SA, Smith GA, Beauregard DA, Hesketh R. Int J Oncol. 2001 Oct;19(4):821-5.

Combretastatin A4-induced differential cytotoxicity and reduced metastatic - Combretastatin A4-induced differential cytotoxicity and reduced metastatic

Lin HL, Chiou SH, Wu CW, Lin WB, Chen LH, Yang YP, Tsai ML, Uen YH, Liou JP, Chi CW. J Pharmacol Exp Ther. 2007 Oct;323(1):365-73. Epub 2007 Jul 23.