Compound 401

• Supplier: Tocris Bioscience
• Catalog: 1495
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 168425-64-7
• Chemical Name: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
• Formula: C16H15N3O2
• Molecular Weight: 281.31
• Purity: >99 %
• Description: Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC 50 values are 0.28 and 5.3 μ M respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC 50 values are all > 100 μ M). Induces apoptosis in vitro .

Product References

Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of - Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of

Griffin RJ, Fontana G, Golding BT, Guiard S, Hardcastle IR, Leahy JJ, Martin N, Richardson C, Rigoreau L, Stockley M, Smith GC. J Med Chem. 2005 Jan 27;48(2):569-85.

Inhibition of mammalian target of rapamycin signaling by - Inhibition of mammalian target of rapamycin signaling by

Ballou LM, Selinger ES, Choi JY, Drueckhammer DG, Lin RZ. J Biol Chem. 2007 Aug 17;282(33):24463-70. Epub 2007 Jun 11.