Compstatin

• Supplier: Tocris Bioscience
• Catalog: 2654
• Prices: $209.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 206645-99-0
• Formula: C66H99N23O17S2
• Molecular Weight: 1550.77
• Description: Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC 50 = 28 μ M) and activation of classical and alternative complement pathways (IC 50 values are 63 and 12 μ M respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons. Control peptide available (Cat. No. 3796).

Product References

Inhibition of human complement by a C3-binding peptide isolated from a - Inhibition of human complement by a C3-binding peptide isolated from a

Sahu A, Kay BK, Lambris JD. J Immunol. 1996 Jul 15;157(2):884-91.

Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig - Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig

Fiane AE, Mollnes TE, Videm V, Hovig T, Hogasen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD. Xenotransplantation. 1999 Feb;6(1):52-65.

Inhibition of heparin/protamine complex-induced complement activation by - Inhibition of heparin/protamine complex-induced complement activation by

Soulika AM, Khan MM, Hattori T, Bowen FW, Richardson BA, Hack CE, Sahu A, Edmunds LH Jr, Lambris JD. Clin Immunol. 2000 Sep;96(3):212-21.