Conantokin G

Name Conantokin G
Supplier Tocris Bioscience
Catalog 3796
Prices $209.00
Sizes 500 µg
Function Type Antagonist
Cas Number 93438-65-4
Formula C88H138N26O44
Molecular Weight 2264.21
Description NR2B-selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC 50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing N2RB, but not NR2A, subunits (IC 50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro .
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Product References

Selective antagonism of nigral neuropeptide responses to methamphetamine by - Selective antagonism of nigral neuropeptide responses to methamphetamine by

Bush L, McCabe T, Hanson GR. Eur J Pharmacol. 2000 Jan 3;387(1):55-8.

Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate - Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate

Donevan SD, McCabe RT. Mol Pharmacol. 2000 Sep;58(3):614-23.

Neuroprotective efficacy and therapeutic window of the high-affinity - Neuroprotective efficacy and therapeutic window of the high-affinity

Williams AJ, Dave JR, Phillips JB, Lin Y, McCabe RT, Tortella FC. J Pharmacol Exp Ther. 2000 Jul;294(1):378-86.