Conantokin-R

Name Conantokin-R
Supplier Tocris Bioscience
Catalog 4136
Prices $279.00
Sizes 500 µg
Function Type Antagonist
Cas Number 202925-60-8
Formula C127H201N35O49S3
Molecular Weight 3098.4
Description Potent, non-competitive NMDA receptor antagonist (IC 50 = 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC 50 = 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activity in vivo at doses devoid of behavioral toxicity.
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Product References

Structure-function relationships of the NMDA receptor antagonist peptide, - Structure-function relationships of the NMDA receptor antagonist peptide,

Blandl T, Warder SE, Prorok M, Castellino FJ. FEBS Lett. 2000 Mar 24;470(2):139-46.

The amino acid residue at sequence position 5 in the conantokin peptides - The amino acid residue at sequence position 5 in the conantokin peptides

Klein RC, Prorok M, Galdzicki Z, Castellino FJ. J Biol Chem. 2001 Jul 20;276(29):26860-7. Epub 2001 May 2.