Conessine

• Supplier: Tocris Bioscience
• Catalog: 2656
• Prices: $139.00
• Sizes: 50 mg
• Function Type: Antagonist
• Cas Number: 546-06-5
• Chemical Name: N,N-Dimethyl-con-5-enin-3-amine
• Formula: C24H40N2
• Molecular Weight: 356.59
• Description: Potent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).

Product References

Isolation, characterization and antiplasmodial activity of steroidal alkaloids - Isolation, characterization and antiplasmodial activity of steroidal alkaloids

Zirihi GN, Grellier P, Guede-Guina F, Bodo B, Mambu L. Bioorg Med Chem Lett. 2005 May 16;15(10):2637-40.

The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. - The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

Zhao C, Sun M, Bennani YL, Gopalakrishnan SM, Witte DG, Miller TR, Krueger KM, Browman KE, Thiffault C, Wetter J, Marsh KC, Hancock AA, Esbenshade TA, Cowart MD. J Med Chem. 2008 Sep 11;51(17):5423-30.