Costunolide

• Supplier: Tocris Bioscience
• Catalog: 3033
• Prices: $85.00, $179.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 553-21-9
• Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
• Formula: C15H20O2
• Molecular Weight: 232.32
• Purity: >97 %
• Description: Inhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF- κ B activation. Displays anti-inflammatory, antifungal and antiviral properties.

Product References

Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a - Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a

Park HJ, Jung WT, Basnet P, Kadota S, Namba T. J Nat Prod. 1996 Dec;59(12):1128-30.

Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR - Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR

Jeong SJ, Itokawa T, Shibuya M, Kuwano M, Ono M, Higuchi R, Miyamoto T. Cancer Lett. 2002 Dec 10;187(1-2):129-33.

Inhibitory effects of costunolide on the telomerase activity in human breast - Inhibitory effects of costunolide on the telomerase activity in human breast

Choi SH, Im E, Kang HK, Lee JH, Kwak HS, Bae YT, Park HJ, Kim ND. Cancer Lett. 2005 Sep 28;227(2):153-62.