(-)-Cotinine

• Supplier: Tocris Bioscience
• Catalog: 2483
• Prices: $75.00
• Sizes: 50 mg
• Cas Number: 486-56-6
• Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
• Formula: C10H12N2O
• Molecular Weight: 176.22
• Purity: >99 %
• Description: Major metabolite of nicotine. Shown to activate a subpopulation of α 3/ α 6 β 2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo ; reduces amyloid β (A β ) aggregation and improves memory in an Alzheimer's disease mouse model.

Product References

The potential role of cotinine in the cognitive and neuroprotective actions of - The potential role of cotinine in the cognitive and neuroprotective actions of

Buccafusco JJ, Terry AV Jr. Life Sci. 2003 May 16;72(26):2931-42.

Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders - Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders

Terry AV Jr, Hernandez CM, Hohnadel EJ, Bouchard KP, Buccafusco JJ. CNS Drug Rev. 2005 Autumn;11(3):229-52.

Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic - Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic

O'Leary K, Parameswaran N, McIntosh JM, Quik M. J Pharmacol Exp Ther. 2008 May;325(2):646-54.

Ultrafiltrate of blood plasma modulates amyloid-beta aggregation. - Ultrafiltrate of blood plasma modulates amyloid-beta aggregation.

Nowicka A, Szczepankiewicz AA, Jaklewicz A, Filipek A, Barcikowska M, Elbaum D. J Alzheimers Dis. 2011;23(1):1-5.