CP 100356 hydrochloride

Name CP 100356 hydrochloride
Supplier Tocris Bioscience
Catalog 3110
Prices $225.00, $925.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 142715-48-8
Chemical Name 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinaminehydrochloride
Formula C31H36N4O6.HCl
Molecular Weight 597.1
Purity >98 %
Description High affinity P-glycoprotein (P-gp) inhibitor (K i values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC 50 = 0.5 μ M) and prazosin transport in BCRP-transfected MDCKII cells (IC 50 = 1.5 μ M). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC 50 > 50 μ M).
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Product References

The equilibrium and kinetic drug binding properties of the mouse P-gp1a and - The equilibrium and kinetic drug binding properties of the mouse P-gp1a and

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N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7- - N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-

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