CP 154526

• Supplier: Tocris Bioscience
• Catalog: 3783
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 257639-98-8
• Chemical Name: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride
• Formula: C23H32N4.HCl
• Molecular Weight: 400.99
• Purity: >99 %
• Description: Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

Product References

A non peptidic corticotropin releasing factor receptor antagonist attenuates - A non peptidic corticotropin releasing factor receptor antagonist attenuates

Lundkvist J, Chai Z, Teheranian R, Hasanvan H, Bartfai T, Jenck F, Widmer U, Moreau JL. Eur J Pharmacol. 1996 Aug 8;309(2):195-200.

Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, - Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526,

Hodgson RA, Higgins GA, Guthrie DH, Lu SX, Pond AJ, Mullins DE, Guzzi MF, Parker EM, Varty GB. Pharmacol Biochem Behav. 2007 Mar;86(3):431-40. Epub 2007 Jan 9.