CP 31398 dihydrochloride

Name CP 31398 dihydrochloride
Supplier Tocris Bioscience
Catalog 3767
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Cas Number 1217195-61-3
Chemical Name N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediaminedihydrochloride
Formula C22H26N4O.2HCl
Molecular Weight 435.39
Purity >99 %
Description p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo .
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Product References

Pharmacological rescue of mutant p53 conformation and function. - Pharmacological rescue of mutant p53 conformation and function.

Foster BA, Coffey HA, Morin MJ, Rastinejad F. Science. 1999 Dec 24;286(5449):2507-10.

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and - CP-31398, a novel p53-stabilizing agent, induces p53-dependent and

Wischhusen J, Naumann U, Ohgaki H, Rastinejad F, Weller M. Oncogene. 2003 Nov 13;22(51):8233-45.

CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect - CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect

Demma MJ, Wong S, Maxwell E, Dasmahapatra B. J Biol Chem. 2004 Oct 29;279(44):45887-96. Epub 2004 Aug 11.