CP 339818 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3542
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 478341-55-8
• Chemical Name: N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1pentanaminehydrochloride
• Formula: C21H24N2.HCl
• Molecular Weight: 340.89
• Purity: >99 %
• Description: Potent, non-peptide K V 1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC 50 ~ 200 nM) . Inhibits K V 1.4 with an IC 50 of ~ 300 nM. Selective over K V 1.1, K V 1.2, K V 1.5, K V 1.6, K V 3.1-4, and K V 4.2.

Product References

Novel nonpeptide agents potently block the C-type inactivated conformation of - Novel nonpeptide agents potently block the C-type inactivated conformation of

Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG. Mol Pharmacol. 1996 Dec;50(6):1672-9.

Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting - Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting

Jager H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S. J Physiol. 1998 Jan 15;506 ( Pt 2):291-301.