CP 376395 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1399
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1013933-37-3
• Chemical Name: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinaminehydrochloride
• Formula: C21H30N2O.HCl
• Molecular Weight: 362.94
• Purity: >99 %
• Description: Potent and selective CRF 1 receptor antagonist (K i values are 12 and >10000 nM for CRF 1 and CRF 2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.

Product References

2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing - 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing

Chen YL, Obach RS, Braselton J, Corman ML, Forman J, Freeman J, Gallaschun RJ, Mansbach R, Schmidt AW, Sprouse JS, Tingley Iii FD, Winston E, Schulz DW. J Med Chem. 2008 Mar 13;51(5):1385-92.

Structure of class B GPCR corticotropin-releasing factor receptor 1. - Structure of class B GPCR corticotropin-releasing factor receptor 1.

Hollenstein K, Kean J, Bortolato A, Cheng RK, Dore AS, Jazayeri A, Cooke RM, Weir M, Marshall FH. Nature. 2013 Jul 25;499(7459):438-43.