CP 424174

• Supplier: Tocris Bioscience
• Catalog: 3212
• Prices: $125.00, $525.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 210825-31-3
• Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
• Formula: C22H29ClN2O4S
• Molecular Weight: 452.99
• Purity: >98 %
• Description: Inhibitor of IL-1 β post-translational processing (IC 50 = 210 nM). Inhibits the formation of mature IL-1 β . Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Product References

Functional characterization of CP-465,022, a selective, noncompetitive AMPA - Functional characterization of CP-465,022, a selective, noncompetitive AMPA

Lazzaro JT, Paternain AV, Lerma J, Chenard BL, Ewing FE, Huang J, Welch WM, Ganong AH, Menniti FS. Neuropharmacology. 2002 Feb;42(2):143-53.

CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA - CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA

Menniti FS, Buchan AM, Chenard BL, Critchett DJ, Ganong AH, Guanowsky V, Seymour PA, Welch WM. Stroke. 2003 Jan;34(1):171-6.

Traditional AMPA receptor antagonists partially block Na v1.6-mediated persistent - Traditional AMPA receptor antagonists partially block Na v1.6-mediated persistent

Welch NC, Lin W, Juranka PF, Morris CE, Stys PK. Neuropharmacology. 2008 Dec;55(7):1165-71.