CP 471474

• Supplier: Tocris Bioscience
• Catalog: 2932
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 210755-45-6
• Chemical Name: 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
• Formula: C16H17FN2O5S
• Molecular Weight: 368.38
• Purity: >97 %
• Description: Broad spectrum MMP inhibitor (IC 50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.

Product References

Matrix metalloproteinase inhibition attenuates early left ventricular enlargement - Matrix metalloproteinase inhibition attenuates early left ventricular enlargement

Rohde LE, Ducharme A, Arroyo LH, Aikawa M, Sukhova GH, Lopez-Anaya A, McClure KF, Mitchell PG, Libby P, Lee RT. Circulation. 1999 Jun 15;99(23):3063-70.

Selective matrix metalloproteinase inhibition reduces left ventricular remodeling - Selective matrix metalloproteinase inhibition reduces left ventricular remodeling

Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT. Circulation. 2002 Feb 12;105(6):753-8.

Differences in inflammation, MMP activation and collagen damage account for - Differences in inflammation, MMP activation and collagen damage account for

Fang L, Gao XM, Moore XL, Kiriazis H, Su Y, Ming Z, Lim YL, Dart AM, Du XJ. J Mol Cell Cardiol. 2007 Nov;43(5):535-44. Epub 2007 Jul 10.