CP 673451

Name	CP 673451
Supplier	Tocris Bioscience
Catalog	0949
Prices	$219.00
Sizes	10 mg
Function Type	Inhibitor
Cas Number	343787-29-1
Chemical Name	1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
Formula	C24H27N5O2
Molecular Weight	417.5
Purity	>98 %
Description	Potent and selective PDGFR inhibitor (IC 50 values are 1 and 10 nM for PDGFR- α and β , resepctively). Selective for PDGFR kinase over a range of related kinases. Inibits PDGFR- β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.
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Product References

Examining the chirality, conformation and selective kinase inhibition of - Examining the chirality, conformation and selective kinase inhibition of

Jiang JK, Ghoreschi K, Deflorian F, Chen Z, Perreira M, Pesu M, Smith J, Nguyen DT, Liu EH, Leister W, Costanzi S, O'Shea JJ, Thomas CJ. J Med Chem. 2008 Dec 25;51(24):8012-8.

Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for - Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for

Flanagan ME, Blumenkopf TA, Brissette WH, Brown MF, Casavant JM, Shang-Poa C, Doty JL, Elliott EA, Fisher MB, Hines M, Kent C, Kudlacz EM, Lillie BM, Magnuson KS, McCurdy SP, Munchhof MJ, Perry BD, Sawyer PS, Strelevitz TJ, Subramanyam C, Sun J, Whipple DA, Changelian PS. J Med Chem. 2010 Dec 23;53(24):8468-84.

Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in - Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in

Dowty ME, Jesson MI, Ghosh S, Lee J, Meyer DM, Krishnaswami S, Kishore N. J Pharmacol Exp Ther. 2014 Jan;348(1):165-73.