| Name | CP 724714 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4556 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 383432-38-0 |
| Chemical Name | 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide |
| Formula | C27H27N5O3 |
| Molecular Weight | 469.53 |
| Purity | >98 % |
| Description | Potent and selective ErbB2 inhibitor (IC 50 = 10 nM). Exhibits 500-1000-fold selectivity for ErbB2 over ErbB1 and other related RTKs. Induces G 1 cell cycle arrest in an ErbB2-overexpressing human cancer cell line. Promotes tumor apoptosis. Induces tumor regression in a human tumor xenograft model. Displays no apparent toxic effect on cardiac tissue. |
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