CP 80633

• Supplier: Tocris Bioscience
• Catalog: 4190
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 135637-46-6
• Chemical Name: 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone
• Formula: C18H24N2O3
• Molecular Weight: 316.39
• Purity: >99 %
• Description: Selective inhibitor of phosphodiesterase type 4 (IC 50 values are 1.9, > 100, > 100, > 100 and > 100 μ M for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells. Displays anti-inflammatory and bronchodilatory effects in vivo .

Product References

In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633. - In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.

Cohan VL, Showell HJ, Fisher DA, Pazoles CJ, Watson JW, Turner CR, Cheng JB. J Pharmacol Exp Ther. 1996 Sep;278(3):1356-61.

The in vivo pharmacology of CP-80, 633, a selective inhibitor of - The in vivo pharmacology of CP-80, 633, a selective inhibitor of

Turner CR, Cohan VL, Cheng JB, Showell HJ, Pazoles CJ, Watson JW. J Pharmacol Exp Ther. 1996 Sep;278(3):1349-55.

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic - The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic

Cheng JB, Watson JW, Pazoles CJ, Eskra JD, Griffiths RJ, Cohan VL, Turner CR, Showell HJ, Pettipher ER. J Pharmacol Exp Ther. 1997 Feb;280(2):621-6.