CP 99994 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2893
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 145148-39-6
• Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinaminedihydrochloride
• Formula: C19H24N2O.2HCl
• Molecular Weight: 369.33
• Purity: >99 %
• Description: High affinity NK 1 antagonist (K i = 0.145 nM in vitro ). Also displays high ex vivo binding potency in gerbil striatum (IC 50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Product References

Endothelium-dependent contraction in intrapulmonary arteries: mediation by - Endothelium-dependent contraction in intrapulmonary arteries: mediation by

Shirahase H, Kanda M, Kurahashi K, Nakamura S, Usui H, Shimizu Y. Br J Pharmacol. 1995 Aug;115(7):1215-20.

Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with - Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with

Duffy RA, Varty GB, Morgan CA, Lachowicz JE. J Pharmacol Exp Ther. 2002 May;301(2):536-42.

Neurokinin 1 receptor antagonists: correlation between in vitro receptor - Neurokinin 1 receptor antagonists: correlation between in vitro receptor

Lindstrom E, von Mentzer B, Pahlman I, Ahlstedt I, Uvebrant A, Kristensson E, Martinsson R, Noven A, de Verdier J, Vauquelin G. J Pharmacol Exp Ther. 2007 Sep;322(3):1286-93. Epub 2007 Jun 15.