CPI 613

• Supplier: Tocris Bioscience
• Catalog: 5331
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 95809-78-2
• Chemical Name: 6,8-Bis[(phenylmethyl)thio]octanoicacid
• Formula: C22H28O2S2
• Molecular Weight: 388.59
• Purity: >99 %
• Description: Pyruvate dehydrogenase (PDH) and α -ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro . Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

Product References

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism - Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism

Zachar Z, Marecek J, Maturo C, Gupta S, Stuart SD, Howell K, Schauble A, Lem J, Piramzadian A, Karnik S, Lee K, Rodriguez R, Shorr R, Bingham PM. J Mol Med (Berl). 2011 Nov;89(11):1137-48.

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase - A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase

Stuart SD, Schauble A, Gupta S, Kennedy AD, Keppler BR, Bingham PM, Zachar Z. Cancer Metab. 2014 Mar 10;2(1):4.