CPPHA

• Supplier: Tocris Bioscience
• Catalog: 0972
• Prices: $195.00
• Sizes: 10 mg
• Function Type: Modulator
• Cas Number: 693288-97-0
• Chemical Name: N-[4-Chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
• Formula: C22H15ClN2O4
• Molecular Weight: 406.82
• Purity: >98 %
• Description: Positive allosteric modulator at mGlu 1 and mGlu 5 ; thought to act at a novel allosteric site. Potentiates mGlu 5 responses by a mechanism distinct from that of VU 29 (Cat. No. 4458).

Product References

A novel selective allosteric modulator potentiates the activity of native - A novel selective allosteric modulator potentiates the activity of native

O'Brien JA, Lemaire W, Wittmann M, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Schaffhauser HJ, Rowe B, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL Jr. J Pharmacol Exp Ther. 2004 May;309(2):568-77. Epub 2004 Jan 27.

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybe - N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybe

Chen Y, Goudet C, Pin JP, Conn PJ. Mol Pharmacol. 2008 Mar;73(3):909-18. Epub 2007 Dec 4.