CPT 11

• Supplier: Tocris Bioscience
• Catalog: 4400
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 100286-90-6
• Chemical Name: (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylicacidesterhydrochloride
• Formula: C33H38N4O6.HCl
• Molecular Weight: 623.14
• Purity: >99 %
• Description: Inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available ( SN 38 , Cat. No. 2684).

Product References

Inhibitory activity of camptothecin derivatives against acetylcholinesterase in - Inhibitory activity of camptothecin derivatives against acetylcholinesterase in

Kawato Y, Sekiguchi M, Akahane K, Tsutomi Y, Hirota Y, Kuga H, Suzuki W, Hakusui H, Sato K. J Pharm Pharmacol. 1993 May;45(5):444-8.

Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against - Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against

Vassal G, Terrier-Lacombe MJ, Bissery MC, Venuat AM, Gyergyay F, Benard J, Morizet J, Boland I, Ardouin P, Bressac-de-Paillerets B, Gouyette A. Br J Cancer. 1996 Aug;74(4):537-45.