Name | 8-CPT-2Me-cAMP, sodium salt |
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Supplier | Tocris Bioscience |
Catalog | 2688 |
Prices | $175.00 |
Sizes | 1 mg |
Function Type | Activator |
Cas Number | 634207-53-7 |
Chemical Name | 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclicmonophosphatesodiumsalt |
Formula | C17H16ClN5O6PS.Na |
Molecular Weight | 507.82 |
Purity | >99 % |
Description | Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC 50 = 2.2 μ M), but not PKA (EC 50 > 10 μ M). Stimulates Epac-mediated Ca 2+ -mediated Ca 2+ release in pancreatic β -cells in vitro . Cell permeable analog (Cat. No. 4853) also available. |
Supplier Page | Shop |
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM. Science. 1998 Dec 18;282(5397):2275-9.
Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Doskeland SO, Blank JL, Bos JL. Nat Cell Biol. 2002 Nov;4(11):901-6.
Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG. J Biol Chem. 2003 Mar 7;278(10):8279-85. Epub 2002 Dec 20.