| Name | CRID3 sodium salt |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1184 |
| Prices | $185.00, $755.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 256373-96-3 |
| Chemical Name | N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamidesodiumsalt |
| Formula | C20H23N2NaO5S |
| Molecular Weight | 426.46 |
| Purity | >97 % |
| Description | Potent NLRP3 inflammasome inhibitor; inhibits IL-1 β production (IC 50 = 7.5 nM). Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis in mice. Also glutathione S -transferase omega 1 inhibitor. Orally bioavailable. |
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Coll RC, Robertson A, Butler M, Cooper M, O'Neill LA. PLoS One. 2011;6(12):e29539.
Coll RC, Robertson AA, Chae JJ, Higgins SC, Munoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Nunez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. Nat Med. 2015 Mar;21(3):248-55.