Crizotinib

• Supplier: Tocris Bioscience
• Catalog: 5479
• Prices: $245.00, $1,005.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 877399-52-5
• Chemical Name: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
• Formula: C21H22Cl2FN5O
• Molecular Weight: 450.34
• Purity: >99 %
• Description: Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC 50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro . Orally bioavailable.

Product References

Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic - Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic

Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, Yamazaki S, Alton GR, Mroczkowski B, Los G. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22.

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits - An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits

Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, Koudriakova TB, Alton G, Cui JJ, Kung PP, Nambu MD, Los G, Bender SL, Mroczkowski B, Christensen JG. Cancer Res. 2007 May 1;67(9):4408-17.

Structure based drug design of crizotinib (PF-02341066), a potent and selective - Structure based drug design of crizotinib (PF-02341066), a potent and selective

Cui JJ, Tran-Dube M, Shen H, Nambu M, Kung PP, Pairish M, Jia L, Meng J, Funk L, Botrous I, McTigue M, Grodsky N, Ryan K, Padrique E, Alton G, Timofeevski S, Yamazaki S, Li Q, Zou H, Christensen J, Mroczkowski B, Bender S, Kania RS, Edwards MP. J Med Chem. 2011 Sep 22;54(18):6342-63.